Change the water (distilled only) and clean the filters on the sides of the chiller. The filters allow for air flow to help the heat exchanger work at optimum performance. If you are in a dusty environment, you may need to clean them more frequently. The water is changed to prevent Algae buildup. You should target changing your water every 3-4 months. If you do develop an algae build up, you will need to perform a system flush.
If your coolant has developed algae, cloudiness, slime, or a green or brown tint, the system needs to be decontaminated, not just refilled. Draining the chiller and topping it off with fresh distilled water will not solve the problem, because the growth is clinging to the inside of the tank, the hoses, and the laser tube's water jacket. The flush below removes it.
Seeing black specks or "floaties" inside your laser tube? This is almost always coolant contamination, not a failed tube. It looks alarming, but a tube does not need to be replaced because of it. Perform the flush below and the particles will clear out with the old coolant.
A flush uses considerably more water than a routine water change. The quantities above cover the 50/50 decontamination fill, both circulation passes, the clean rinse, and the final refill. Running short partway through and topping off with tap water undoes the entire job, so it is worth having the full amount on hand before you start.
When pinching the hose, use firm, steady pressure with the flat of your fingers. Do not crimp hard enough to kink the hose or put strain on the barbs and fittings. If a hose has gone stiff or discolored with age, do not force it — replace it instead.
Do not skip the air purge. An air pocket trapped in the tube jacket creates a hot spot on the glass and can crack a tube that was otherwise perfectly good.